Ergosterol peroxide from flowers of Erigeron annuus L. as an anti-atherosclerosis agent

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Title
Ergosterol peroxide from flowers of Erigeron annuus L. as an anti-atherosclerosis agent
Author(s)
D H Kim; S J Jung; I S Chung; Y H Lee; D K Kim; S H Kim; Byoung-Mog KwonTae Sook Jeong; M H Park; N S Seoung; N I Baek
Bibliographic Citation
Archives of Pharmacal Research, vol. 28, no. 5, pp. 541-545
Publication Year
2005
Abstract
Flowers of Erigeron annuus L. were extracted with 80% aqueous MeOH, and the concentrated extract was partitioned with EtOAc, n-BuOH, and H2O. Repeated silica gel and ODS column chromatography of the EtOAc fraction led to the isolation of a sterol, through activityguided fractionation, using ACAT inhibitory activity measurements. From the physico-chemical data, including NMR, MS, and IR, the chemical structure of the compound was determined to be an ergosterol peroxide (1), which has been isolated for the first time from this plant. This compound exhibited hACAT-1 and Lp-PLA2 inhibitory effects, with inhibitory values of 51.6 ± 0.9 and 51.7 ± 1.2%, at a treatment concentration of 0.23 mM.
Keyword
CompositaeErgosterol peroxideErigeron annuus L.haCAT1 inhibitory effect
ISSN
0253-6269
Publisher
Pharmaceutical Soc Korea
DOI
http://dx.doi.org/10.1007/BF02977755
Type
Article
Appears in Collections:
Division of Biomedical Research > Genome Editing Research Center > 1. Journal Articles
Division of Biomaterials Research > Industrial Bio-materials Research Center > 1. Journal Articles
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