Coumarins and chromones from Angelica genuflexa

Cited 0 time in scopus
Metadata Downloads
Title
Coumarins and chromones from Angelica genuflexa
Author(s)
Ren Bo An; Bo Young Park; Jung Hee KimOk Kyoung Kwon; Joongku Lee; Byung Sun Min; Kyung Seop AhnSei Ryang Oh; Hyeong Kyu Lee
Bibliographic Citation
Natural Products Sciences, vol. 11, no. 2, pp. 79-84
Publication Year
2005
Abstract
Thirteen compounds were isolated from the roots of Angelica genuflexa through repeated silica gel column chromatography. Nine coumarins, isoimperatorin (1), osthol (2), demethylsuberosin (3), oxypeucedanin (4), heraclenin (5), pabulenol (7), umbelliferone (8), oxypeucedanin hydrate (9) and marmesinin (11), and four chromones, hamaudol (6), cimifugin (10), sec-O-glucosylhamaudol (12) and prim-O-glucosylcimifugin (13), were identified by physicochemical and spectroscopic analysis. Among these, compounds 3, 5, 6, 8, 12, and 13 were isolated for the first time from the roots of Angelica genuflexa. These coumarins and chromones were examined for their anticomplement activity. Demethylsuberosin (3) showed a weak anticomplement activity with an IC50 value of 390 μM.
Keyword
angelica genuflexaanticomplement activitydemethylsuberosinhamaudolheracleninprim-O-glucosylcimifuginsec-O-glucosylhamaudolumbelliferone
ISSN
I000-0147
Publisher
Korean Society of Pharmacognosy
Type
Article
Appears in Collections:
Ochang Branch Institute > Natural Medicine Research Center > 1. Journal Articles
Ochang Branch Institute > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.