Coumarins and chromones from Angelica genuflexa

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Coumarins and chromones from Angelica genuflexa
Ren Bo An; Bo Young Park; Jung Hee KimOk Kyoung Kwon; Joongku Lee; Byung Sun Min; Kyung Seop AhnSei Ryang Oh; Hyeong Kyu Lee
Bibliographic Citation
Natural Products Sciences, vol. 11, no. 2, pp. 79-84
Publication Year
Thirteen compounds were isolated from the roots of Angelica genuflexa through repeated silica gel column chromatography. Nine coumarins, isoimperatorin (1), osthol (2), demethylsuberosin (3), oxypeucedanin (4), heraclenin (5), pabulenol (7), umbelliferone (8), oxypeucedanin hydrate (9) and marmesinin (11), and four chromones, hamaudol (6), cimifugin (10), sec-O-glucosylhamaudol (12) and prim-O-glucosylcimifugin (13), were identified by physicochemical and spectroscopic analysis. Among these, compounds 3, 5, 6, 8, 12, and 13 were isolated for the first time from the roots of Angelica genuflexa. These coumarins and chromones were examined for their anticomplement activity. Demethylsuberosin (3) showed a weak anticomplement activity with an IC50 value of 390 μM.
anticomplement activityangelica genuflexademethylsuberosinhamaudolheracleninprim-O-glucosylcimifuginsec-O-glucosylhamaudolumbelliferone
Korean Society of Pharmacognosy
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Ochang Branch Institute > Division of National Bio-Infrastructure > Bio-Resource Central Bank > 1. Journal Articles
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
Ochang Branch Institute > 1. Journal Articles
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