Compound IKD-8344, a selective growth inhibitor against the mycelial form of Candida albicans, isolated from Streptomyces sp. A6792

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Title
Compound IKD-8344, a selective growth inhibitor against the mycelial form of Candida albicans, isolated from Streptomyces sp. A6792
Author(s)
E I Hwang; Bong Sik Yun; W H Yeo; S H Lee; Jae Sun Moon; Young Kook Kim; S J Lim; Sung Uk Kim
Bibliographic Citation
Journal of Microbiology and Biotechnology, vol. 15, no. 4, pp. 909-912
Publication Year
2005
Abstract
In the course of screening for selective growth inhibitors against the mycelial form of Candida albicans, we isolated a Streptomyces sp. A6792 from soils. The inhibitor was isolated from the above bacterium and identified through several spectral analyses with UV and mass spectrophotometries, and various NMR. The compound was determined to be a macrocyclic dilactone antibiotic, IKD-8344 (molecular weight: 844, molecular formula: C48H76O12). The compound selectively inhibited the growth of mycelial form of C. albicans with an MIC of 6.25 μg/ml. It also exhibited strong inhibitory effect preferentially on the mycelial form of various Candida spp. including C. krusei, C. tropicalis, and C. lusitaniae, with MICs ranging from 1.56 to 25 μg/ml. Furthermore, the compound showed no significant toxicity against SPF ICR mice up to 60 mg/kg. These results suggest that IKD-8344 is a useful lead compound for the development of novel antifungal agents, based on the preferential growth inhibition against Candida spp.
Keyword
candida albicansdimorphismIKD-8344morphological changeselectivityvirulence
ISSN
1017-7825
Publisher
Korea Soc-Assoc-Inst
Type
Article
Appears in Collections:
Division of Research on National Challenges > Plant Systems Engineering Research > 1. Journal Articles
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