Open Access@KRIBBSynthetic Biology and Bioengineering Research InstituteSynthetic Biology Research Center1. Journal Articles
Antibody engineering for the development of therapeutic antibodies
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- Title
- Antibody engineering for the development of therapeutic antibodies
- Author(s)
- Sang Jick Kim; Young Woo Park; Hyo Jeong Hong
- Bibliographic Citation
- Molecules and Cells, vol. 20, no. 1, pp. 17-29
- Publication Year
- 2005
- Abstract
- Therapeutic antibodies represent one of the fastest growing areas of the pharmaceutical industry. There are currently 19 monoclonal antibodies in the market that have been approved by the FDA and over 150 in clinical developments. Driven by innovation and technological developments, therapeutic antibodies are the second largest biopharmaceutical product category after vaccines. Antibodies have been engineered by a variety of methods to suit a particular therapeutic use. This review describes the structural and functional characteristics of antibody and the antibody engineering for the generation and optimization of therapeutic antibodies.
- Keyword
- affinity Maturationantibody engineeringantibody fragmentseffector functionshuman monoclonal antibodieshumanized antibodiespharmacokineticstherapeutic antibodies
- ISSN
- 1016-8478
- Publisher
- Korea Soc-Assoc-Inst
- Type
- Article
- Appears in Collections:
- Synthetic Biology and Bioengineering Research Institute > Synthetic Biology Research Center > 1. Journal Articles
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