Induction of apoptotic cell death by 2′-hydroxycinnamaldehyde is involved with ERK-dependent inactivation of NF-κB in TNF-α-treated SW620 colon cancer cells = 하드록시 신남알데하이드에서 유고되는

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Title
Induction of apoptotic cell death by 2′-hydroxycinnamaldehyde is involved with ERK-dependent inactivation of NF-κB in TNF-α-treated SW620 colon cancer cells = 하드록시 신남알데하이드에서 유고되는
Author(s)
S H Lee; C W Lee; J W Lee; M S Choi; D J Son; Y B Chung; C K Lee; K W Oh; D C Moon; Byoung-Mog Kwon; J T Hong
Bibliographic Citation
Biochemical Pharmacology, vol. 70, no. 8, pp. 1147-1157
Publication Year
2005
Abstract
2′-Hydroxycinnamaldehyde (HCA) inhibits cell growth of several human cancer cells with unknown mechanisms. We investigated the inhibitory effect of HCA on TNF-α-induced cell growth and possible signal pathway in SW620 colon cancer cells. HCA inhibited TNF-α-induced SW620 colon cell growth in time- and dose-dependent manner through induction of apoptotic cell death. Parallel with inhibitory effect on cell growth, HCA dose dependency inhibited TNF-α-induced activation of NF-κB accompanied with inhibition of the translocation of p50. HCA also induced expression of caspase-3 and Bax, but decreased Bcl-2. HCA furthermore activated ERK pathway, and ERK inhibitor reversed inhibitory effect of HCA on cell growth and transcriptional activation of NF-κB. These results demonstrate that HCA inhibits cell growth through induction of apoptotic cell death by ERK pathway-dependent NF-κB inactivation.
Keyword
2′-HydroxycinnamaldehydeApoptotic cell deathColon cancerERKNF-κB
ISSN
0006-2952
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.bcp.2005.07.028
Type
Article
Appears in Collections:
Division of Biomedical Research > Genome Editing Research Center > 1. Journal Articles
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