A flavonoid from medicinal plants blocks hepatitis B virus-e antigen secretion in HBV-infected hepatocytes

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Title
A flavonoid from medicinal plants blocks hepatitis B virus-e antigen secretion in HBV-infected hepatocytes
Author(s)
Min Soo Shin; Eun hwa Kang; Young Ik Lee
Bibliographic Citation
Antiviral Research, vol. 67, no. 3, pp. 163-168
Publication Year
2005
Abstract
A flavonoid molecule that showed a unique anti-HBV function was isolated from Phyllanthus urinaria. The molecular formula was determined as C 14H6O8 based on FAM-MS analysis and the structure was determined by NMR. The identified flavonoid molecule, ellagic acid, showed unique anti-HBV functions. Ellagic acid did not inhibit either HBV polymerase activity, HBV replication or block HBsAg secretion. Rather, ellagic acid blocks effectively HBeAg secretion in HepG2 2.2.15 cells (IC50 = 0.07 μg/ml). Since HBeAg is involved in immune tolerance during HBV infection, ellagic acid, a newly identified functional anti-HBV compound, may be a new candidate therapeutic against immune tolerance in HBV-infected individuals.
Keyword
HBeAg secretionHepatitis B virus-e antigenNMR spectrometerPhyllanthus urinaria
ISSN
0166-3542
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.antiviral.2005.06.005
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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