Binding and regulation of hypoxia-inducible factor-1 by the inhibitory PAS proteins = 저해성 PAS 단백질에 의한 HIF-1a 단백질의 조절

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dc.contributor.authorMi Sun Jang-
dc.contributor.authorJae Eun Park-
dc.contributor.authorJung A Lee-
dc.contributor.authorSung Goo Park-
dc.contributor.authorP K Myung-
dc.contributor.authorDo Hee Lee-
dc.contributor.authorByoung Chul Park-
dc.contributor.authorSayeon Cho-
dc.date.accessioned2017-04-19T09:03:22Z-
dc.date.available2017-04-19T09:03:22Z-
dc.date.issued2005-
dc.identifier.issn0006291X-
dc.identifier.uri10.1016/j.bbrc.2005.09.038ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/7094-
dc.description.abstractHypoxia-inducible factor-1 (HIF-1), which consists of oxygen-sensitive HIF-1α and constitutively expressed HIF-1β subunits, activates transcription of genes encoding proteins that mediate adaptive responses to reduced oxygen availability. The mouse inhibitory PAS (Per/Arnt/Sim) domain protein (IPAS) functions as a negative regulator in HIF-mediated gene expression. In this report, we cloned the human orthologs of the mouse IPAS gene, IPASH1 and IPASH2, to further study the regulatory mechanism of HIF-1 by the IPAS proteins. The human IPAS proteins inhibited the transactivation function of HIF-1α under hypoxic conditions. In addition, human IPAS proteins blocked the hypoxia-induced VEGF expression and inhibited cell migration and tube formation of human umbilical vein endothelial cells. Interestingly, both HIF-1α and HIF-1β interacted with the IPAS proteins. Collectively, these results suggest that human IPAS proteins inhibit angiogenesis by binding to and inhibiting HIF-1α and HIF-1β.-
dc.publisherElsevier-
dc.titleBinding and regulation of hypoxia-inducible factor-1 by the inhibitory PAS proteins = 저해성 PAS 단백질에 의한 HIF-1a 단백질의 조절-
dc.title.alternativeBinding and regulation of hypoxia-inducible factor-1 by the inhibitory PAS proteins-
dc.typeArticle-
dc.citation.titleBiochemical and Biophysical Research Communications-
dc.citation.number1-
dc.citation.endPage215-
dc.citation.startPage209-
dc.citation.volume337-
dc.contributor.affiliatedAuthorSung Goo Park-
dc.contributor.affiliatedAuthorByoung Chul Park-
dc.contributor.alternativeName장미선-
dc.contributor.alternativeName박재은-
dc.contributor.alternativeName이정아-
dc.contributor.alternativeName박성구-
dc.contributor.alternativeName명평근-
dc.contributor.alternativeName이도희-
dc.contributor.alternativeName박병철-
dc.contributor.alternativeName조사연-
dc.identifier.bibliographicCitationBiochemical and Biophysical Research Communications, vol. 337, no. 1, pp. 209-215-
dc.identifier.doi10.1016/j.bbrc.2005.09.038-
dc.subject.keywordAngiogenesis-
dc.subject.keywordHypoxia-
dc.subject.keywordHypoxia-inducible factor-1α-
dc.subject.keywordInhibitory PAS domain protein-
dc.subject.localAngiogenesis-
dc.subject.localHypoxia-
dc.subject.localHypoxia-inducible factor-1α-
dc.subject.localhypoxia inducible factor-1α (HIF-1α)-
dc.subject.localInhibitory PAS domain protein-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Disease Target Structure Research Center > 1. Journal Articles
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