Neuroprotective and free radical scavenging activities of phenolic compounds from Hovenia dulcis = Hovenia dulcis로부터 분리한 phenolic compounds의 neuroprotective와 free radical scavenging activities

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Title
Neuroprotective and free radical scavenging activities of phenolic compounds from Hovenia dulcis = Hovenia dulcis로부터 분리한 phenolic compounds의 neuroprotective와 free radical scavenging activities
Author(s)
Gao Li; B S Min; C Zheng; Joongku Lee; Sei Ryang OhKyung Seop Ahn; Hyeong Kyu Lee
Bibliographic Citation
Archives of Pharmacal Research, vol. 28, no. 7, pp. 804-809
Publication Year
2005
Abstract
The EtOAc-soluble fraction from a methanolic extract of Hovenia dulcis Thunb. exhibited neuroprotective activity against glutamate-induced neurotoxicity in mouse hippocampal HT22 cells. The neuroprotective activity-guided isolation resulted in 8 phenolic compounds (1-8), such as vanillic acid (1), ferulic acid (2), 3,5-dihydroxystilbene (3), (+)-aromadendrin (4), methyl vanillate (5), (-)-catechin (6), 2,3,4-trihydrobenzoic acid (7), and (+)-afzelechin (8). Among these, compounds 6 and 8 had a neuroprotective effect on the glutamate-induced neurotoxicity in HT22 cells. Furthermore, compound 6 had a DPPH free radical scavenging effect with an IC50 value of 57.7 μM, and a superoxide anion radical scavenging effect with an IC50 value of 8.0 μM. Both compounds 6 and 8 had ABTS cation radical scavenging effects with IC50 values of 7.8 μM and 23.7 μM, respectively. These results suggest that compounds 6 and 8 could be neuroprotectants owing to their free radical scavenging activities.
Keyword
(+)-Afzelechin(-)-CatechinABTSDPPHHovenia dulcisHT22 CellsNeuroprotectionSuperoxide
ISSN
0253-6269
Publisher
Pharmaceutical Soc Korea
DOI
http://dx.doi.org/10.1007/BF02977346
Type
Article
Appears in Collections:
Ochang Branch Institute > 1. Journal Articles
Ochang Branch Institute > Natural Medicine Research Center > 1. Journal Articles
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