Fungal metabolites, sorbicillinoid polyketides and their effects on the activation of peroxisome proliferator-activated receptor γ

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Title
Fungal metabolites, sorbicillinoid polyketides and their effects on the activation of peroxisome proliferator-activated receptor γ
Author(s)
Dongho Lee; Jeong-Hyung Lee; X F Cai; Jin Chul Shin; Kyeong Lee; Young-Soo Hong; Jung Joon Lee
Bibliographic Citation
Journal of Antibiotics, vol. 58, no. 10, pp. 615-620
Publication Year
2005
Abstract
A new sorbicillinoid polyketide, dihydrotrichodimerol (2), along with known trichodimerol (1), and rezishanones C (3) and D (4) were isolated by bioassay-guided fractionation from an unidentified fungal strain. Dihydrotrichodimerol (2) specifically activated peroxisome proliferator- activated receptor γ with an ED50 value of 80 ng/ml as measured by a transactivation assay using a chimeric hPPAR/GAL4 system without affecting peroxisome proliferator-activated receptors α and δ. On the other hand, compounds 1 and 2 suppressed the production of tumor necrosis factor-α and nitric oxide in LPS-stimulated RAW264.7 cells to a similar extent.
Keyword
Nitric oxidePeroxisome proliferator-activated receptor γSorbicillinoidTrichodimerol derivativeTumor necrosis factor-α
ISSN
0021-8820
Publisher
Springer-Nature Pub Group
DOI
http://dx.doi.org/10.1038/ja.2005.84
Type
Article
Appears in Collections:
Ochang Branch Institute > Anticancer Agent Research Center > 1. Journal Articles
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