The finding of new genetic polymorphism of UCP-1 A-1766G and its effects on body fat accumulation

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Title
The finding of new genetic polymorphism of UCP-1 A-1766G and its effects on body fat accumulation
Author(s)
K S Kim; D Y Cho; Young Joo Kim; S M Choi; J Y Kim; S U Shin; Y S Yoon
Bibliographic Citation
Biochimica et Biophysica Acta-Molecular Basis of Disease, vol. 1741, no. 1, pp. 149-155
Publication Year
2005
Abstract
A-1766G polymorphism, for the first time, has been found in the sequencing of pooled and individual genomic DNA of Korean subjects at the 5′ flanking region of the UCP-1 gene. The effects of new polymorphism on body fat were elucidated among 387 Korean female subjects. It was shown that the genotypes AA, AG, and GG were consisted of 57.4%, 37.7%, and 4.9%, respectively, which was in agreement with Hardy-Weinberg equilibrium (P=0.327). The frequency of major A allele was 0.762 and that of minor G allele was 0.238. It is found that the waist-hip ratio (WHR) (P=0.008), body fat mass (P=0.023), and percent body fat (P=0.014) are significantly higher in the AG/GG type compared to the AA type. When the subjects were analyzed using computerized tomography, there were significant increases in the AG/GG type compared to the AA type in the abdominal subcutaneous fat (P=0.015) and the abdominal visceral fat (P=0.013), respectively. A-1766G is approximately 2 kb downstream from the well-known A-3826G polymorphism, and no linkage between them was found (D′=0.929, R2=0.283). Three haplotypes (frequency >0.05) were examined from two polymorphisms and studied for their physiological effects. It was found that haplotype [GG] was significantly associated with increased body fat, while haplotype [GA] was associated with decreased body fat.
Keyword
A-1766GfathaplotypepolymorphismSNPUCP-1
ISSN
0925-4439
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.bbadis.2004.11.026
Type
Article
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1. Journal Articles > Journal Articles
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