Monoamine oxidase inhibitory constituents from the fruits of Cudrania tricuspidata

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Title
Monoamine oxidase inhibitory constituents from the fruits of Cudrania tricuspidata
Author(s)
X H Han; S S Hong; J S Hwang; S H Jeong; J H Hwang; M H Lee; M K Lee; Dongho Lee; J S Ro; B Y Hwang
Bibliographic Citation
Archives of Pharmacal Research, vol. 28, no. 12, pp. 1324-1327
Publication Year
2005
Abstract
A methylene chloride soluble fraction of the fruits of Cudrania tricuspidata significantly inhibited the mouse brain monoamine oxidase (MAO). Three known prenylated isoflavones were isolated and identified by activity-guided fractionation. Gancaonin A (1), 4′-O- methylalpinumisoflavone (2), and alpinumisoflavone (3) inhibited MAO activity in a concentration-dependent manner with IC50 values of 19.4, 23.9, and 25.8 μM, respectively. of these, gancaonin A (1) showed a selective and potent inhibitory effect against MAO-B (IC50 0.8 μM) than MAO-A (IC50 >800 μM). The kinetic analysis using Lineweaver-Burk plots indicated that gancaonin A (1) competitively inhibited MAO-B.
Keyword
cudrania tricuspidatagancaonin Amonoamine oxidase inhibitormoraceaeprenylated isoflavone
ISSN
0253-6269
Publisher
Pharmaceutical Soc Korea
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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