Protein tyrosine phosphatase 1B inhibitors from Morus root bark

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Title
Protein tyrosine phosphatase 1B inhibitors from Morus root bark
Author(s)
L Cui; Min Kyun Na; H Oh; Eun Young Bae; Dae Gwin Jeong; Seong Eon Ryu; S Kim; Bo Yeon Kim; Won Keun Oh; Jong Seog Ahn
Bibliographic Citation
Bioorganic & Medicinal Chemistry Letters, vol. 16, no. 5, pp. 1426-1429
Publication Year
2006
Abstract
An organic layer prepared from the Chinese crude drug 'Sang-Bai-Pi' (Morus root bark) was studied in order to identify the inhibitory compounds for protein tyrosine phosphatase 1B (PTP1B). Bioassay-guided fractionation resulted in the isolation of sanggenon C (1), sanggenon G (2), mulberrofuran C (3) and kuwanon L (4) as PTP1B inhibitors, along with moracin O (5) and moracin P (6). Compounds 1-4 inhibited PTP1B with IC50 values ranging from 1.6 ± 0.3 μM to 16.9 ± 1.1 μM.
Keyword
kuwanon L.morus root barkmulberrofuran Cprotein tyrosine phosphatase 1Bsanggenon Csanggenon G
ISSN
0960-894X
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.bmcl.2005.11.071
Type
Article
Appears in Collections:
Division of Research on National Challenges > Bionanotechnology Research Center > 1. Journal Articles
Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
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