Human ACAT-1 and ACAT-2 inhibitory activities of pentacyclic triterpenes from the leaves of Lycopus lucidus Turcz. = 택란 잎으로부터 분리한 pentacyclic triterpenes의 사람 ACAT-1과 ACAT-2 저해 활성

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Title
Human ACAT-1 and ACAT-2 inhibitory activities of pentacyclic triterpenes from the leaves of Lycopus lucidus Turcz. = 택란 잎으로부터 분리한 pentacyclic triterpenes의 사람 ACAT-1과 ACAT-2 저해 활성
Author(s)
Woo Song Lee; Kyung Ran Im; Yong Dae Park; N D Sung; Tae Sook Jeong
Bibliographic Citation
Biological & Pharmaceutical Bulletin, vol. 29, no. 2, pp. 382-384
Publication Year
2006
Abstract
Acyl-CoA: cholesterol acyltransferase (ACAT) catalyzes the acylation of cholesterol to cholesteryl ester with long chain fatty acids and ACAT inhibition is a useful strategy for treating hypercholesterolemia or atherosclerosis. Pentacyclic triterpenes, ursolic acid (1), oleanolic acid (2), and betulinic acid (3) were isolated from the methanol extracts of the leaves of Lycopus lucidus TURCZ. by bioassay-guided fractionation. The structures of compounds 1-3 were elucidated by their spectroscopic data analysis. Among them, betulinic acid (3) exhibited more potent human ACAT-1 and ACAT-2 inhibitory activities with IC50 values of 16.2±0.6 and 28.8±1.3 μM, respectively.
Keyword
Acyl-CoAAtherosclerosisCholesterol acytransferase (ACAT)Lycopus lucidusPentacyclic triterpene
ISSN
0918-6158
Publisher
Pharmaceutical Soc Japan
DOI
http://dx.doi.org/10.1248/bpb.29.382
Type
Article
Appears in Collections:
Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
Division of Biomaterials Research > Industrial Bio-materials Research Center > 1. Journal Articles
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