DC Field | Value | Language |
---|---|---|
dc.contributor.author | Su Kyung Lee | - |
dc.contributor.author | Jung Min Kim | - |
dc.contributor.author | Mi Young Lee | - |
dc.contributor.author | Kwang Hee Son | - |
dc.contributor.author | Young Il Yeom | - |
dc.contributor.author | C H Kim | - |
dc.contributor.author | Y Shin | - |
dc.contributor.author | J S Koh | - |
dc.contributor.author | Dong Cho Han | - |
dc.contributor.author | Byoung-Mog Kwon | - |
dc.date.accessioned | 2017-04-19T09:04:06Z | - |
dc.date.available | 2017-04-19T09:04:06Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 0020-7136 | - |
dc.identifier.uri | 10.1002/ijc.21610 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/7296 | - |
dc.description.abstract | As farnesylation of the Ras protein by farnesyl transferase is a critical step for the Ras functional activity, the farnesyl transferase inhibitor could affect H-Ras functions and the inhibitors such as arteminolide, SCH66336 and LB42908 completely inhibited Ras-farnesylation. However, they did not induce apoptosis of H-Ras-transformed cells with concentration for blocking H-Ras farnesylation. To determine the antitumor effects of the inhibitors, it was analyzed through the expression profile of genes, regulated by activated H-Ras or FTIs by using cDNA microarray. On the basis of the results, the relationship between H-Ras and MMPs expression was confirmed by RT-PCR, Western bolt, zymographic analysis and angiogenesis assay. Our results suggested that activation of MMP-13 as well as MMP-9 induced by H-Ras is involved in angiogenesis and with farnesyl transferase inhibitors, in part, exerts their anticancer effects. We confirmed that MMP-13 is a critical H-Ras target gene through chemical genomic approaches with farnesyl transferase inhibitors. | - |
dc.publisher | Wiley | - |
dc.title | Confirmation of a linkage between H-Ras and MMP-13 expression as well as MMP-9 by chemical genomic approach = 화학유전체 연구방법을 이용한 라스 활성과 신생혈관 형성과의 관계 규명 | - |
dc.title.alternative | Confirmation of a linkage between H-Ras and MMP-13 expression as well as MMP-9 by chemical genomic approach | - |
dc.type | Article | - |
dc.citation.title | International Journal of Cancer | - |
dc.citation.number | 9 | - |
dc.citation.endPage | 2181 | - |
dc.citation.startPage | 2172 | - |
dc.citation.volume | 118 | - |
dc.contributor.affiliatedAuthor | Su Kyung Lee | - |
dc.contributor.affiliatedAuthor | Jung Min Kim | - |
dc.contributor.affiliatedAuthor | Mi Young Lee | - |
dc.contributor.affiliatedAuthor | Kwang Hee Son | - |
dc.contributor.affiliatedAuthor | Young Il Yeom | - |
dc.contributor.affiliatedAuthor | Dong Cho Han | - |
dc.contributor.affiliatedAuthor | Byoung-Mog Kwon | - |
dc.contributor.alternativeName | 이수경 | - |
dc.contributor.alternativeName | 김정민 | - |
dc.contributor.alternativeName | 이미영 | - |
dc.contributor.alternativeName | 손광희 | - |
dc.contributor.alternativeName | 염영일 | - |
dc.contributor.alternativeName | 김철희 | - |
dc.contributor.alternativeName | 신유승 | - |
dc.contributor.alternativeName | 고종성 | - |
dc.contributor.alternativeName | 한동초 | - |
dc.contributor.alternativeName | 권병목 | - |
dc.identifier.bibliographicCitation | International Journal of Cancer, vol. 118, no. 9, pp. 2172-2181 | - |
dc.identifier.doi | 10.1002/ijc.21610 | - |
dc.subject.keyword | cDNA microarray | - |
dc.subject.keyword | Farnesyl transferase | - |
dc.subject.keyword | Gene expression profile | - |
dc.subject.keyword | H-Ras | - |
dc.subject.keyword | MMPs chemical genomics | - |
dc.subject.local | cDNA micro-array | - |
dc.subject.local | cDNA microarray | - |
dc.subject.local | Farnesyl transferase | - |
dc.subject.local | Farnesyltransferase | - |
dc.subject.local | farnesyltransferase | - |
dc.subject.local | Gene expression profile | - |
dc.subject.local | Gene expression profiles | - |
dc.subject.local | gene expression profile | - |
dc.subject.local | H-Ras | - |
dc.subject.local | H-ras | - |
dc.subject.local | MMPs chemical genomics | - |
dc.description.journalClass | Y | - |
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