Confirmation of a linkage between H-Ras and MMP-13 expression as well as MMP-9 by chemical genomic approach = 화학유전체 연구방법을 이용한 라스 활성과 신생혈관 형성과의 관계 규명

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dc.contributor.authorSu Kyung Lee-
dc.contributor.authorJung Min Kim-
dc.contributor.authorMi Young Lee-
dc.contributor.authorKwang Hee Son-
dc.contributor.authorYoung Il Yeom-
dc.contributor.authorC H Kim-
dc.contributor.authorY Shin-
dc.contributor.authorJ S Koh-
dc.contributor.authorDong Cho Han-
dc.contributor.authorByoung-Mog Kwon-
dc.date.accessioned2017-04-19T09:04:06Z-
dc.date.available2017-04-19T09:04:06Z-
dc.date.issued2006-
dc.identifier.issn0020-7136-
dc.identifier.uri10.1002/ijc.21610ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/7296-
dc.description.abstractAs farnesylation of the Ras protein by farnesyl transferase is a critical step for the Ras functional activity, the farnesyl transferase inhibitor could affect H-Ras functions and the inhibitors such as arteminolide, SCH66336 and LB42908 completely inhibited Ras-farnesylation. However, they did not induce apoptosis of H-Ras-transformed cells with concentration for blocking H-Ras farnesylation. To determine the antitumor effects of the inhibitors, it was analyzed through the expression profile of genes, regulated by activated H-Ras or FTIs by using cDNA microarray. On the basis of the results, the relationship between H-Ras and MMPs expression was confirmed by RT-PCR, Western bolt, zymographic analysis and angiogenesis assay. Our results suggested that activation of MMP-13 as well as MMP-9 induced by H-Ras is involved in angiogenesis and with farnesyl transferase inhibitors, in part, exerts their anticancer effects. We confirmed that MMP-13 is a critical H-Ras target gene through chemical genomic approaches with farnesyl transferase inhibitors.-
dc.publisherWiley-
dc.titleConfirmation of a linkage between H-Ras and MMP-13 expression as well as MMP-9 by chemical genomic approach = 화학유전체 연구방법을 이용한 라스 활성과 신생혈관 형성과의 관계 규명-
dc.title.alternativeConfirmation of a linkage between H-Ras and MMP-13 expression as well as MMP-9 by chemical genomic approach-
dc.typeArticle-
dc.citation.titleInternational Journal of Cancer-
dc.citation.number9-
dc.citation.endPage2181-
dc.citation.startPage2172-
dc.citation.volume118-
dc.contributor.affiliatedAuthorSu Kyung Lee-
dc.contributor.affiliatedAuthorJung Min Kim-
dc.contributor.affiliatedAuthorMi Young Lee-
dc.contributor.affiliatedAuthorKwang Hee Son-
dc.contributor.affiliatedAuthorYoung Il Yeom-
dc.contributor.affiliatedAuthorDong Cho Han-
dc.contributor.affiliatedAuthorByoung-Mog Kwon-
dc.contributor.alternativeName이수경-
dc.contributor.alternativeName김정민-
dc.contributor.alternativeName이미영-
dc.contributor.alternativeName손광희-
dc.contributor.alternativeName염영일-
dc.contributor.alternativeName김철희-
dc.contributor.alternativeName신유승-
dc.contributor.alternativeName고종성-
dc.contributor.alternativeName한동초-
dc.contributor.alternativeName권병목-
dc.identifier.bibliographicCitationInternational Journal of Cancer, vol. 118, no. 9, pp. 2172-2181-
dc.identifier.doi10.1002/ijc.21610-
dc.subject.keywordcDNA microarray-
dc.subject.keywordFarnesyl transferase-
dc.subject.keywordGene expression profile-
dc.subject.keywordH-Ras-
dc.subject.keywordMMPs chemical genomics-
dc.subject.localcDNA micro-array-
dc.subject.localcDNA microarray-
dc.subject.localFarnesyl transferase-
dc.subject.localFarnesyltransferase-
dc.subject.localGene expression profiles-
dc.subject.localgene expression profile-
dc.subject.localGene expression profile-
dc.subject.localH-Ras-
dc.subject.localH-ras-
dc.subject.localMMPs chemical genomics-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
Division of Biomedical Research > Personalized Genomic Medicine Research Center > 1. Journal Articles
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