Inhibitory activity of 6-O-angeloylprenolin from Centipeda minima on farnesyl protein transferase = 식물체로부터 FPTase 저해제 분리

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Title
Inhibitory activity of 6-O-angeloylprenolin from Centipeda minima on farnesyl protein transferase = 식물체로부터 FPTase 저해제 분리
Author(s)
Hyun Mi Oh; Byoung-Mog Kwon; N I Baek; S H Kim; J H Lee; J S Eun; J H Yang; D K Kim
Bibliographic Citation
Archives of Pharmacal Research, vol. 29, no. 1, pp. 64-66
Publication Year
2006
Abstract
The methanolic extract of the aerial parts of Centipeda minima was found to show inhibitory activity on famesyl protein transferase (FPTase). Bioassay-guided fractionation of the methanolic extract resulted in the isolation of 6-O-angeloylprenolin, as an inhibitor on FPTase. This compound inhibited FPTase activity in a dose-dependent manner, and the IC50 value of 6-O-angeloylprenolin was 18.8 μM.
Keyword
6-O-AngeloylprenolinCentipeda minimaFPTase
ISSN
0253-6269
Publisher
Pharmaceutical Soc Korea
DOI
http://dx.doi.org/10.1007/BF02977470
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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