Inhibitory activity of 6-O-angeloylprenolin from Centipeda minima on farnesyl protein transferase = 식물체로부터 FPTase 저해제 분리
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- Title
- Inhibitory activity of 6-O-angeloylprenolin from Centipeda minima on farnesyl protein transferase = 식물체로부터 FPTase 저해제 분리
- Author(s)
- Hyun Mi Oh; Byoung-Mog Kwon; N I Baek; S H Kim; J H Lee; J S Eun; J H Yang; D K Kim
- Bibliographic Citation
- Archives of Pharmacal Research, vol. 29, no. 1, pp. 64-66
- Publication Year
- 2006
- Abstract
- The methanolic extract of the aerial parts of Centipeda minima was found to show inhibitory activity on famesyl protein transferase (FPTase). Bioassay-guided fractionation of the methanolic extract resulted in the isolation of 6-O-angeloylprenolin, as an inhibitor on FPTase. This compound inhibited FPTase activity in a dose-dependent manner, and the IC50 value of 6-O-angeloylprenolin was 18.8 μM.
- ISSN
- 0253-6269
- Publisher
- Pharmaceutical Soc Korea
- Full Text Link
- http://dx.doi.org/10.1007/BF02977470
- Type
- Article
- Appears in Collections:
- 1. Journal Articles > Journal Articles
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