Acyl-CoA: cholesterol acyltransferase inhibitors from Ilex macropoda = 대패집나무로부터 분리한 ACAT 저해제

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Title
Acyl-CoA: cholesterol acyltransferase inhibitors from Ilex macropoda = 대패집나무로부터 분리한 ACAT 저해제
Author(s)
K R Im; Tae Sook Jeong; Byoung-Mog Kwon; N I Baek; S H Kim; D K Kim
Bibliographic Citation
Archives of Pharmacal Research, vol. 29, no. 3, pp. 191-194
Publication Year
2006
Abstract
Twigs from Ilex macropoda were extracted with MeOH, and the concentrated extracts were partitioned with CH2Cl2, EtOAc, n-BuOH, and H2O. Repeated column chromatography of the CH2Cl 2 fraction ultimately resulted in the isolation of two compounds, via activity-guided fractionation, using ACAT inhibitory activity measurements. According to the physico-chemical data, the chemical structures of these isolated compounds were identified as lupeol (1) and betulin (2). Compounds 1 and 2 were shown to inhibit the activity of hACAT-1 and hACAT-2 in a dose-dependent manner, and compounds 1 and 2 inhibited hACAT-1 with IC50 values of 48 and 83 μM, respectively.
Keyword
ACAT inhibitory activityBetulinIlex macropodaLupeol
ISSN
0253-6269
Publisher
Pharmaceutical Soc Korea
DOI
http://dx.doi.org/10.1007/BF02969391
Type
Article
Appears in Collections:
Division of Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
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