Suppressive effect of verproside isolated from Pseudolysimachion longifolium on airway inflammation in a mouse model of allergic asthma = 긴산꼬리풀에서 추출한 verproside의 알러지성 천식 동물모델 염증
Cited 47 time in
- Title
- Suppressive effect of verproside isolated from Pseudolysimachion longifolium on airway inflammation in a mouse model of allergic asthma = 긴산꼬리풀에서 추출한 verproside의 알러지성 천식 동물모델 염증
- Author(s)
- Sei Ryang Oh; Mee Young Lee; Kyung Seop Ahn; B Y Park; Ok Kyong Kwon; Hyouk Joung; Joongku Lee; Doo-Young Kim; Sangku Lee; J H Kim; Hyeong Kyu Lee
- Bibliographic Citation
- International Immunopharmacology, vol. 6, no. 6, pp. 978-986
- Publication Year
- 2006
- Abstract
- Allergic inflammation of the airways has a critical role in asthma development. We investigated a suppressive effect of verproside (3,4-dihydroxy catalpol) isolated from the extract of Pseudolysimachion longifolium on asthmatic parameters-such as immunoglobulin E (IgE) level, cytokine release, eosinophilia, airway hyperresponsiveness and mucus hypersecretion-in an OVA-sensitized/challenged mouse model. Verproside significantly inhibited the increase of total IgE and the cytokines IL-4 and IL-13 in plasma and bronchoalveolar lavage fluid, and also effectively suppressed airway hyperresponsiveness, eosinophilia and mucus hypersecretion in OVA-induced asthmatic mice. The efficacy of verproside was comparable to montelukast, an anti-asthmatic drug that is currently available. These results suggest that verproside could be a major marker in herbal medicines that are used for asthma treatment, and could also act as a lead for anti-asthmatic drugs.
- Keyword
- allergic asthmamouse modelpseudolysimachion longifoliumverproside
- ISSN
- 1567-5769
- Publisher
- Elsevier
- DOI
- http://dx.doi.org/10.1016/j.intimp.2006.01.010
- Type
- Article
- Appears in Collections:
- Ochang Branch Institute > 1. Journal Articles
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
Ochang Branch Institute > Division of National Bio-Infrastructure > Bio-Resource Central Bank > 1. Journal Articles
Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
- Files in This Item:
Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.