Suppressive effect of verproside isolated from Pseudolysimachion longifolium on airway inflammation in a mouse model of allergic asthma = 긴산꼬리풀에서 추출한 verproside의 알러지성 천식 동물모델 염증

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Title
Suppressive effect of verproside isolated from Pseudolysimachion longifolium on airway inflammation in a mouse model of allergic asthma = 긴산꼬리풀에서 추출한 verproside의 알러지성 천식 동물모델 염증
Author(s)
Sei Ryang Oh; Mee Young Lee; Kyung Seop Ahn; B Y Park; Ok Kyong Kwon; Hyouk Joung; Joongku Lee; Doo-Young KimSangku Lee; J H Kim; Hyeong Kyu Lee
Bibliographic Citation
International Immunopharmacology, vol. 6, no. 6, pp. 978-986
Publication Year
2006
Abstract
Allergic inflammation of the airways has a critical role in asthma development. We investigated a suppressive effect of verproside (3,4-dihydroxy catalpol) isolated from the extract of Pseudolysimachion longifolium on asthmatic parameters-such as immunoglobulin E (IgE) level, cytokine release, eosinophilia, airway hyperresponsiveness and mucus hypersecretion-in an OVA-sensitized/challenged mouse model. Verproside significantly inhibited the increase of total IgE and the cytokines IL-4 and IL-13 in plasma and bronchoalveolar lavage fluid, and also effectively suppressed airway hyperresponsiveness, eosinophilia and mucus hypersecretion in OVA-induced asthmatic mice. The efficacy of verproside was comparable to montelukast, an anti-asthmatic drug that is currently available. These results suggest that verproside could be a major marker in herbal medicines that are used for asthma treatment, and could also act as a lead for anti-asthmatic drugs.
Keyword
allergic asthmamouse modelpseudolysimachion longifoliumverproside
ISSN
1567-5769
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.intimp.2006.01.010
Type
Article
Appears in Collections:
Ochang Branch Institute > 1. Journal Articles
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
Ochang Branch Institute > Division of National Bio-Infrastructure > Bio-Resource Central Bank > 1. Journal Articles
Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
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