Streptokordin, a new cytotoxic compound of the methylpyridine class from a marine-derived Streptomyces sp. KORDI-3238

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Title
Streptokordin, a new cytotoxic compound of the methylpyridine class from a marine-derived Streptomyces sp. KORDI-3238
Author(s)
S Y Jeong; H J Shin; T S Kim; H S Lee; Song Kyu Park; Hwan Mook Kim
Bibliographic Citation
Journal of Antibiotics, vol. 59, no. 4, pp. 234-240
Publication Year
2006
Abstract
A new cytotoxic compound, streptokordin, and four known compounds, nonactic acid, dilactone, trilactone, and nonactin, were isolated from the fermentation broth of a marine actinomycete strain collected in deep-sea sediments. Biochemical tests and 16S rDNA analysis indicated that the strain belongs to the genus Streptomyces. This actinomycete produces various bioactive secondary metabolites. Fractionations by solvent partitioning, silica vacuum flash chromatography, and reversed-phase HPLC gave a pure cytotoxic compound, designated streptokordin. Its structure was elucidated by FAB-MS, 1H, 13C, and 2D NMR spectroscopy. Streptokordin exhibited significant cytotoxicity against seven human cancer cell lines but showed no growth inhibition against various microorganisms including bacteria and fungi.
Keyword
16S rDNA4-acetyl-6-methyl-1-H-pyridine-2-onecytotoxicmethylpyridinestreptomyces sp. KORDI-3238
ISSN
0021-8820
Publisher
Springer-Nature Pub Group
DOI
http://dx.doi.org/10.1038/ja.2006.33
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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