Role of E2F1 in endoplasmic reticulum stress signaling

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Title
Role of E2F1 in endoplasmic reticulum stress signaling
Author(s)
Kyung Mi Park; Dong Joon Kim; Sang Gi Paik; Soo Jung Kim; Young Il Yeom
Bibliographic Citation
Molecules and Cells, vol. 21, no. 3, pp. 356-359
Publication Year
2006
Abstract
The transcription factor E2F1 coordinates cell cycle progression and induces apoptosis in response to DNA damage stress. Aside from DNA damage, the role of E2F1 in the endoplasmic reticulum (ER) stress signaling pathways is unclear. We found that E2Fl-/- murine embryonic fibroblasts (MEFs) are resistant to apoptosis triggered by the ER stress inducer thapsigargin. In addition, E2F1 deficiency results in enhanced phosphorylation of eukaryotic translation initiation factor 2α (eIF2α). These results therefore indicate that E2F1 deficiency increases phosphorylation of eIF2α in response to ER stress triggered by thapsigargin, and suggest that the reduction in ER stress-induced apoptosis. in E2F1 deficient cells is related to the high level of eIF2α phosphorylation.
Keyword
E2F1endoplasmic reticulum stresseukaryotic translation initiation factor 2α (eIF2α)thapsigargin
ISSN
1016-8478
Publisher
Korea Soc-Assoc-Inst
Type
Article
Appears in Collections:
Division of Biomedical Research > Personalized Genomic Medicine Research Center > 1. Journal Articles
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