Anti-complementary activity of ursane-type triterpenoids from Weigela subsessilis

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Anti-complementary activity of ursane-type triterpenoids from Weigela subsessilis
P T Thuong; B S Min; W Y Jin; M K Na; J P Lee; R S Seong; Y M Lee; K S Song; Y H Seong; Hyeong Kyu Lee; K H Bae; S S Kang
Bibliographic Citation
Biological & Pharmaceutical Bulletin, vol. 29, no. 4, pp. 830-833
Publication Year
A new ursane-type triterpenoid, weigelic acid (1), and seven known compounds, ursolic acid (2), ilekudinol A (3), corosolic acid (4), ilekudinol B (5), esculentic acid (6), pomolic acid (7), and asiatic acid (8) were isolated from the leaf and stem of Weigela subsessilis. The structure of the new triterpenoid was established as 1β,2α,3α,23-tetrahydroxyurs-12- en-28-oic acid on the basis of spectroscopic analyses. In addition, the isolated compounds were evaluated for their anti-complement activity against the classical pathway of the complement system. of these, compounds 1 - 2 and 4 - 8 exhibited anti-complement activity with IC50 values of 152, 90, 130, 51, 56, 4, and 163 μM, respectively, whereas 3 was inactive. This shows that a carboxylic group of ursane-type triterpenoids seems to play an important role in inhibiting the hemolytic activity of human serum against erythrocytes.
Anti-complementaryCaprifoliaceaeUrsane-type triterpenoidWeigela subsessilisWeigelic acid
Pharmaceutical Soc Japan
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