Hepatocellular carcinoma model cell lines with two distinct migration modes

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Hepatocellular carcinoma model cell lines with two distinct migration modes
I J Lee; Z S Li; Y N Lee; X J Jin; Jeong-Hyung Lee; Seon-Young KimNam-Soon KimDong Chul Lee; Heun-Sik Lee; S J Yang; Soo Jung Kim; Young Il Yeom
Bibliographic Citation
Biochemical and Biophysical Research Communications, vol. 346, no. 4, pp. 1217-1227
Publication Year
Migration is an essential feature of metastatic cancer cells. To understand how motility is regulated in hepatocellular carcinoma, we analyzed gene expression profiles of mouse model cell lines we established from transgenic mice carrying SV40 large T antigen. A non-motile HC9 cell line was isolated from mouse liver tumors, and two additional cell lines, HCM1 and HCM4, were derived from HC9 cells. We found that both HCM1 and HCM4 cells were substantially more migratory than HC9, and that HCM1 generated tumor nodules in nude mice. In contrast to HCM4 cells that exhibited mesenchymal cell-type gene expression similar to HC9 cells, HCM1 cells appeared to have undergone a mesenchymal-amoeboidal transition. Thus, HCM1 and HCM4 cells have distinct migration and gene expression patterns, and together with HC9 cells, they can serve as model cell lines for understanding how migration is acquired and controlled in hepatocellular carcinoma.
Gene expression profilesHepatocellular carcinomaMesenchymalMesenchymal-amoeboidal transitionMigration
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Division of Biomedical Research > Rare Disease Research Center > 1. Journal Articles
Division of Biomedical Research > Personalized Genomic Medicine Research Center > 1. Journal Articles
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