Antioxidant activities of abietane diterpenoids isolated from Torreya nucifera leaves

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Title
Antioxidant activities of abietane diterpenoids isolated from Torreya nucifera leaves
Author(s)
Woo Song Lee; J R Kim; Jong Min Han; K C Jang; D E Sok; Tae Sook Jeong
Bibliographic Citation
Journal of Agricultural and Food Chemistry, vol. 54, no. 15, pp. 5369-5374
Publication Year
2006
Abstract
Investigation on antioxidant compounds from the ethanolic extracts of Torreya nucifera leaves resulted in the isolation of abietane diterpenoids, a known 18-methylesterferruginol (1) and a new 18-dimethoxyferruginol (2). The structures of compounds 1 and 2 were elucidated on the basis of their spectroscopic analyses. Compounds 1 and 2 inhibited the Cu2+- mediated, 2,2′-azobis(2-amidino-propane)hydrochloride-mediated and 3-morpholinosydnonimine-1-mediated low-density lipoprotein (LDL) oxidation in the thiobarbituric acid-reactive substances assay as well as the macrophage-mediated LDL oxidation. Compounds 1 and 2 exhibited the potent antioxidant activities in the conjugated diene production, relative electrophoretic mobility, and apoB-100 fragmentation on copper-mediated LDL oxidation. Compound 1 also suppressed nitric oxide production and inducible nitric oxide synthase expression in lipopolysaccharide-stimulated RAW264.7 cells.
Keyword
Abietane diterpenoidsAntioxidant activityAtherosclerosisINOSLDLNOTorreya nucifera
ISSN
0021-8561
Publisher
Amer Chem Soc
DOI
http://dx.doi.org/10.1021/jf060896c
Type
Article
Appears in Collections:
Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
Division of Biomaterials Research > Industrial Bio-materials Research Center > 1. Journal Articles
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