Synthesis and biological evaluation of rhodanine derivatives as PRL-3 inhibitors = PRL-3의 inhibitor인 rhodanine유도체들의 합성과 생물학적 평가

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Title
Synthesis and biological evaluation of rhodanine derivatives as PRL-3 inhibitors = PRL-3의 inhibitor인 rhodanine유도체들의 합성과 생물학적 평가
Author(s)
J H Ahn; Seung Jun Kim; W S Park; S Y Cho; J D Ha; S S Kim; S K Kang; Dae Gwin Jeong; Suk-Kyeong Jung; Sang-Hyeup Lee; Hwan Mook Kim; Song Kyu Park; Kiho Lee; Chang Woo Lee; Seong Eon Ryu; J K Choi
Bibliographic Citation
Bioorganic & Medicinal Chemistry Letters, vol. 16, no. 11, pp. 2996-2999
Publication Year
2006
Abstract
A series of rhodanine derivatives was synthesized and evaluated for their ability to inhibit PRL-3. Benzylidene rhodanine derivative showed good biological activity, while compound 5e was the most active in this series exhibiting an IC50 value of 0.9 μM in vitro and showed a reduced invasion in cell-based assay.
Keyword
cancerinhibitormetastasisPRL-3rhodanine
ISSN
0960-894X
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.bmcl.2006.02.060
Type
Article
Appears in Collections:
Division of Research on National Challenges > Infectious Disease Research Center > 1. Journal Articles
Ochang Branch Institute > Division of Bioinfrastructure > Laboratory Animal Resource Center > 1. Journal Articles
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