Synthesis and biological evaluation of rhodanine derivatives as PRL-3 inhibitors = PRL-3의 inhibitor인 rhodanine유도체들의 합성과 생물학적 평가
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- Title
- Synthesis and biological evaluation of rhodanine derivatives as PRL-3 inhibitors = PRL-3의 inhibitor인 rhodanine유도체들의 합성과 생물학적 평가
- Author(s)
- J H Ahn; Seung Jun Kim; W S Park; S Y Cho; J D Ha; S S Kim; S K Kang; Dae Gwin Jeong; Suk-Kyeong Jung; Sang-Hyeup Lee; Hwan Mook Kim; Song Kyu Park; Kiho Lee; Chang Woo Lee; Seong Eon Ryu; J K Choi
- Bibliographic Citation
- Bioorganic & Medicinal Chemistry Letters, vol. 16, no. 11, pp. 2996-2999
- Publication Year
- 2006
- Abstract
- A series of rhodanine derivatives was synthesized and evaluated for their ability to inhibit PRL-3. Benzylidene rhodanine derivative showed good biological activity, while compound 5e was the most active in this series exhibiting an IC50 value of 0.9 μM in vitro and showed a reduced invasion in cell-based assay.
- ISSN
- 0960-894X
- Publisher
- Elsevier
- Full Text Link
- http://dx.doi.org/10.1016/j.bmcl.2006.02.060
- Type
- Article
- Appears in Collections:
- Critical Diseases Diagnostics Convergence Research Center > 1. Journal Articles
Division of Research on National Challenges > Bionanotechnology Research Center > 1. Journal Articles
Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
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