SNP@Domain: a web resource of single nucleotide polymorphisms (SNPs) within protein domain structures and sequences

Cited 19 time in scopus
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Title
SNP@Domain: a web resource of single nucleotide polymorphisms (SNPs) within protein domain structures and sequences
Author(s)
Areum Han; H J Kang; Y Cho; Sung Hoon Lee; Young Joo Kim; Sungsam Gong
Bibliographic Citation
Nucleic Acids Research, vol. 34, no. W, pp. W642-W644
Publication Year
2006
Abstract
The single nucleotide polymorphisms (SNPs) in conserved protein regions have been thought to be strong candidates that alter protein functions. Thus, we have developed SNPΔomain, a web resource, to identify SNPs within human protein domains. We annotated SNPs from dbSNP with protein structure-based as well as sequence-based domains: (i) structure-based using SCOP and (ii) sequence-based using Pfam to avoid conflicts from two domain assignment methodologies. Users can investigate SNPs within protein domains with 2D and 3D maps. We expect this visual annotation of SNPs within protein domains will help scientists select and interpret SNPs associated with diseases. A web interface for the SNPΔomain is freely available at http://snpnavigator.net/ and from http://bioportal.net/.
ISSN
0305-1048
Publisher
Oxford Univ Press
DOI
http://dx.doi.org/10.1093/nar/gkl323
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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