Hormonal activity of AIMP1/p43 for glucose homeostasis

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Title
Hormonal activity of AIMP1/p43 for glucose homeostasis
Author(s)
S G Park; Y S Kang; J Y Kim; C S Lee; Y G Ko; W J Lee; K U Lee; Young Il Yeom; S Kim
Bibliographic Citation
Proceedings of National Academy of Sciences of United States of America, vol. 103, no. 40, pp. 14913-14918
Publication Year
2006
Abstract
AIMP1/p43 is known as a cytokine working in the control of angiogenesis, inflammation, and wound healing. Here we report its enrichment in pancreatic a cells and glucagon-like hormonal activity. AIMP1 is secreted from the pancreas upon glucose starvation. Exogenous infusion of AIMP1 increased plasma levels of glucose, glucagon, and fatty acid, and AIMP1-deficient mice showed reduced plasma glucose levels compared with the wild-type mice under fasting conditions. Thus, AIMP1 plays a glucagon-like role in glucose homeostasis.
Keyword
aminoacyl-tRNA synthetaseglucagonpancreas
ISSN
0027-8424
Publisher
Natl Acad Sciences
DOI
http://dx.doi.org/10.1073/pnas.0602045103
Type
Article
Appears in Collections:
Division of Biomedical Research > Personalized Genomic Medicine Research Center > 1. Journal Articles
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