8-Hydroxydihydrochelerythrine and 8-Hydroxydihydrosanguinarine with a potent acetylcholinesterase inhibitory activity from Chelidonium majus L.

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Title
8-Hydroxydihydrochelerythrine and 8-Hydroxydihydrosanguinarine with a potent acetylcholinesterase inhibitory activity from Chelidonium majus L.
Author(s)
K M Cho; Ick Dong Yoo; Won Gon Kim
Bibliographic Citation
Biological & Pharmaceutical Bulletin, vol. 29, no. 11, pp. 2317-2320
Publication Year
2006
Abstract
Ethanol extract of the aerial portion of Chelidonium majus L. inhibited acetylcholinesterase (AChE) activity without a significant inhibition of butyrylcholinesterase (BuChE). Using mass spectrometry and NMR studies, three active constituents were isolated and identified: 8-hydroxydihydrochelerythrine (1), 8-hydroxydihydrosanguinarine (2), and berberine (3). Compounds 1-3 showed potent inhibitory activity against AChE, with IC50 (μmM) values of 0.61-1.85. Compound 1 exhibited competitive and selective inhibition for AChE.
Keyword
8-hydroxydihydrosanguinarineacetylcholinesterasechelidonium majus L8-hydroxydihydrochelerythrine
ISSN
0918-6158
Publisher
Pharmaceutical Soc Japan
DOI
http://dx.doi.org/10.1248/bpb.29.2317
Type
Article
Appears in Collections:
Division of Research on National Challenges > Infectious Disease Research Center > 1. Journal Articles
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