Open Access@KRIBBDivision of Research on National ChallengesInfectious Disease Research Center1. Journal Articles
8-Hydroxydihydrochelerythrine and 8-Hydroxydihydrosanguinarine with a potent acetylcholinesterase inhibitory activity from Chelidonium majus L.
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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | K M Cho | - |
| dc.contributor.author | Ick Dong Yoo | - |
| dc.contributor.author | Won Gon Kim | - |
| dc.date.accessioned | 2017-04-19T09:05:23Z | - |
| dc.date.available | 2017-04-19T09:05:23Z | - |
| dc.date.issued | 2006 | - |
| dc.identifier.issn | 0918-6158 | - |
| dc.identifier.uri | 10.1248/bpb.29.2317 | ko |
| dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/7625 | - |
| dc.description.abstract | Ethanol extract of the aerial portion of Chelidonium majus L. inhibited acetylcholinesterase (AChE) activity without a significant inhibition of butyrylcholinesterase (BuChE). Using mass spectrometry and NMR studies, three active constituents were isolated and identified: 8-hydroxydihydrochelerythrine (1), 8-hydroxydihydrosanguinarine (2), and berberine (3). Compounds 1-3 showed potent inhibitory activity against AChE, with IC50 (μmM) values of 0.61-1.85. Compound 1 exhibited competitive and selective inhibition for AChE. | - |
| dc.publisher | Pharmaceutical Soc Japan | - |
| dc.title | 8-Hydroxydihydrochelerythrine and 8-Hydroxydihydrosanguinarine with a potent acetylcholinesterase inhibitory activity from Chelidonium majus L. | - |
| dc.title.alternative | 8-Hydroxydihydrochelerythrine and 8-Hydroxydihydrosanguinarine with a potent acetylcholinesterase inhibitory activity from Chelidonium majus L. | - |
| dc.type | Article | - |
| dc.citation.title | Biological & Pharmaceutical Bulletin | - |
| dc.citation.number | 11 | - |
| dc.citation.endPage | 2320 | - |
| dc.citation.startPage | 2317 | - |
| dc.citation.volume | 29 | - |
| dc.contributor.affiliatedAuthor | Ick Dong Yoo | - |
| dc.contributor.affiliatedAuthor | Won Gon Kim | - |
| dc.contributor.alternativeName | 조경미 | - |
| dc.contributor.alternativeName | 유익동 | - |
| dc.contributor.alternativeName | 김원곤 | - |
| dc.identifier.bibliographicCitation | Biological & Pharmaceutical Bulletin, vol. 29, no. 11, pp. 2317-2320 | - |
| dc.identifier.doi | 10.1248/bpb.29.2317 | - |
| dc.subject.keyword | 8-hydroxydihydrochelerythrine | - |
| dc.subject.keyword | 8-hydroxydihydrosanguinarine | - |
| dc.subject.keyword | acetylcholinesterase | - |
| dc.subject.keyword | chelidonium majus L | - |
| dc.subject.local | 8-hydroxydihydrochelerythrine | - |
| dc.subject.local | 8-hydroxydihydrosanguinarine | - |
| dc.subject.local | Acetylcholinesterase (AChE) | - |
| dc.subject.local | acetylcholinesterase | - |
| dc.subject.local | Acetylcholinesterase | - |
| dc.subject.local | chelidonium majus L | - |
| dc.description.journalClass | Y | - |
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