Open Access@KRIBBDivision of Research on National ChallengesInfectious Disease Research Center1. Journal Articles
8-Hydroxydihydrochelerythrine and 8-Hydroxydihydrosanguinarine with a potent acetylcholinesterase inhibitory activity from Chelidonium majus L.
Cited 68 time in 
Metadata Downloads
- Title
- 8-Hydroxydihydrochelerythrine and 8-Hydroxydihydrosanguinarine with a potent acetylcholinesterase inhibitory activity from Chelidonium majus L.
- Author(s)
- K M Cho; Ick Dong Yoo; Won Gon Kim
- Bibliographic Citation
- Biological & Pharmaceutical Bulletin, vol. 29, no. 11, pp. 2317-2320
- Publication Year
- 2006
- Abstract
- Ethanol extract of the aerial portion of Chelidonium majus L. inhibited acetylcholinesterase (AChE) activity without a significant inhibition of butyrylcholinesterase (BuChE). Using mass spectrometry and NMR studies, three active constituents were isolated and identified: 8-hydroxydihydrochelerythrine (1), 8-hydroxydihydrosanguinarine (2), and berberine (3). Compounds 1-3 showed potent inhibitory activity against AChE, with IC50 (μmM) values of 0.61-1.85. Compound 1 exhibited competitive and selective inhibition for AChE.
- Keyword
- 8-hydroxydihydrosanguinarineacetylcholinesterasechelidonium majus L8-hydroxydihydrochelerythrine
- ISSN
- 0918-6158
- Publisher
- Pharmaceutical Soc Japan
- Full Text Link
- http://dx.doi.org/10.1248/bpb.29.2317
- Type
- Article
- Appears in Collections:
- Division of Research on National Challenges > Infectious Disease Research Center > 1. Journal Articles
- Files in This Item:
There are no files associated with this item.
Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.