DC Field | Value | Language |
---|---|---|
dc.contributor.author | You Ra Lee | - |
dc.contributor.author | Byoung Chul Park | - |
dc.contributor.author | Do Hee Lee | - |
dc.contributor.author | Kwang-Hee Bae | - |
dc.contributor.author | S Cho | - |
dc.contributor.author | C H Lee | - |
dc.contributor.author | Jong Suk Lee | - |
dc.contributor.author | P K Myung | - |
dc.contributor.author | Sung Goo Park | - |
dc.date.accessioned | 2017-04-19T09:05:24Z | - |
dc.date.available | 2017-04-19T09:05:24Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 1016-8478 | - |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/7626 | - |
dc.description.abstract | Uric acid is the end product of the purine degradation pathway in humans. It is catabolized to allantoin by urate oxidase or uricase (E.C. 1.7.3.3.) in most vertebrates except humans, some primates, birds, and certain species of reptiles. Here we provide evidence that mouse transthyretin-related protein facilitates the hydrolysis of 5-hydroxyisourate, the end product of the uricase reaction. Mutagenesis experiments showed that the residues that are absolutely conserved across the TRP family, including His11, Arg51, His102, and the Cterminal Tyr-Arg-Gly-Ser, may constitute the active site of mTRP. Based on these results, we propose that the transthyretin-related proteins present in diverse organisms are not functionally related to transthyretin but actually function as hydroxyisourate hydrolases. | - |
dc.publisher | Korea Soc-Assoc-Inst | - |
dc.title | Mouse transthyretin-related protein is a hydrolase which degrades 5-Hydroxyisourate, the end product of the uricase reaction | - |
dc.title.alternative | Mouse transthyretin-related protein is a hydrolase which degrades 5-Hydroxyisourate, the end product of the uricase reaction | - |
dc.type | Article | - |
dc.citation.title | Molecules and Cells | - |
dc.citation.number | 2 | - |
dc.citation.endPage | 145 | - |
dc.citation.startPage | 141 | - |
dc.citation.volume | 22 | - |
dc.contributor.affiliatedAuthor | You Ra Lee | - |
dc.contributor.affiliatedAuthor | Byoung Chul Park | - |
dc.contributor.affiliatedAuthor | Do Hee Lee | - |
dc.contributor.affiliatedAuthor | Kwang-Hee Bae | - |
dc.contributor.affiliatedAuthor | Jong Suk Lee | - |
dc.contributor.affiliatedAuthor | Sung Goo Park | - |
dc.contributor.alternativeName | 이유라 | - |
dc.contributor.alternativeName | 박병철 | - |
dc.contributor.alternativeName | 이도희 | - |
dc.contributor.alternativeName | 배광희 | - |
dc.contributor.alternativeName | 조사연 | - |
dc.contributor.alternativeName | 이충환 | - |
dc.contributor.alternativeName | 이종석 | - |
dc.contributor.alternativeName | 명평근 | - |
dc.contributor.alternativeName | 박성구 | - |
dc.identifier.bibliographicCitation | Molecules and Cells, vol. 22, no. 2, pp. 141-145 | - |
dc.subject.keyword | hydroxyisourate | - |
dc.subject.keyword | transthyretin-related proteins | - |
dc.subject.keyword | uric acid | - |
dc.subject.keyword | uricase | - |
dc.subject.local | hydroxyisourate | - |
dc.subject.local | transthyretin-related proteins | - |
dc.subject.local | uric acid | - |
dc.subject.local | uricase | - |
dc.description.journalClass | Y | - |
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