Mouse transthyretin-related protein is a hydrolase which degrades 5-Hydroxyisourate, the end product of the uricase reaction

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Title
Mouse transthyretin-related protein is a hydrolase which degrades 5-Hydroxyisourate, the end product of the uricase reaction
Author(s)
You Ra Lee; Byoung Chul Park; Do Hee Lee; Kwang-Hee Bae; S Cho; C H Lee; Jong Suk Lee; P K Myung; Sung Goo Park
Bibliographic Citation
Molecules and Cells, vol. 22, no. 2, pp. 141-145
Publication Year
2006
Abstract
Uric acid is the end product of the purine degradation pathway in humans. It is catabolized to allantoin by urate oxidase or uricase (E.C. 1.7.3.3.) in most vertebrates except humans, some primates, birds, and certain species of reptiles. Here we provide evidence that mouse transthyretin-related protein facilitates the hydrolysis of 5-hydroxyisourate, the end product of the uricase reaction. Mutagenesis experiments showed that the residues that are absolutely conserved across the TRP family, including His11, Arg51, His102, and the Cterminal Tyr-Arg-Gly-Ser, may constitute the active site of mTRP. Based on these results, we propose that the transthyretin-related proteins present in diverse organisms are not functionally related to transthyretin but actually function as hydroxyisourate hydrolases.
Keyword
hydroxyisouratetransthyretin-related proteinsuric aciduricase
ISSN
1016-8478
Publisher
Korea Soc-Assoc-Inst
Type
Article
Appears in Collections:
Critical Diseases Diagnostics Convergence Research Center > 1. Journal Articles
Division of Biomedical Research > Metabolic Regulation Research Center > 1. Journal Articles
Division of Biomedical Research > Disease Target Structure Research Center > 1. Journal Articles
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