Dykellic acid inhibits cell migration and tube formation by RhoA-GTP expression = 다이켈릭산이 RhoA-GTP 발현에 의해 세포이동과 tube 형성을 저해

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Title
Dykellic acid inhibits cell migration and tube formation by RhoA-GTP expression = 다이켈릭산이 RhoA-GTP 발현에 의해 세포이동과 tube 형성을 저해
Author(s)
J C Heo; J Y Park; S U Woo; J R Rho; Ho Jae Lee; Sung Uk Kim; Yung Hee Kho; S H Lee
Bibliographic Citation
Biological & Pharmaceutical Bulletin, vol. 29, no. 11, pp. 2256-2259
Publication Year
2006
Abstract
Dykellic acid, a novel factor initially identified from the culture broth of Westerdykella multispora F50733, has been shown to inhibit matrix metalloprotease 9 activity, caspase-3 activity, B cell proliferation and LPS-induced IgM production, suggesting that this factor may have anti-cancer effects. In an effort to further address the possible anti-tumoral effects of dykellic acid, we used wound healing, invasion and RhoA-GTP assays to examine the effects of dykellic acid on cell migration, invasion and angiogenesis. Our results revealed that dykellic acid dose-dependently inhibits B16 cell migration and motility, and inhibits HUVEC tube formation. Western blot analysis of the active form of RhoA (RhoA-GTP) showed that dykellic acid treatment decreased the levels of RhoA-GTP. These findings collectively suggest that dykellic acid may have both anti-metastatic and antiangiogenic acitivites, and provides the first evidence for the involvement of RhoA in dykellic acid-induced effects.
Keyword
AngiogenesisCell migrationDykellic acidInvasionRhoARhoA-GTP
ISSN
0918-6158
Publisher
Pharmaceutical Soc Japan
DOI
http://dx.doi.org/10.1248/bpb.29.2256
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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