Analysis of a prodigiosin biosynthetic gene cluster from the marine bacterium Hahella chejuensis KCTC 2396 = 해양세균 하헬라 제주엔시스의 프로디지오신 생합성 유전자 군 분석

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Title
Analysis of a prodigiosin biosynthetic gene cluster from the marine bacterium Hahella chejuensis KCTC 2396 = 해양세균 하헬라 제주엔시스의 프로디지오신 생합성 유전자 군 분석
Author(s)
D Kim; Yon Kyoung Park; Jong Suk Lee; Jihyun Kim; Haeyoung Jeong; B S Kim; C H Lee
Bibliographic Citation
Journal of Microbiology and Biotechnology, vol. 16, no. 12, pp. 1912-1918
Publication Year
2006
Abstract
Marine bacterium Hahella chejuensis KCTC 2396 simultaneously produced red antibiotic prodigiosin and undecylprodiginine. A complete set of the prodigiosin biosynthetic gene cluster has been cloned, sequenced, and successfully expressed in a heterologous host. Sequence analysis of the gene cluster revealed 14 ORFs showing high similarity to pig and red genes from Serratia spp. and Streptomyces coelicolor A3(2), respectively, and the gene organization was almost similar to that of pig genes. These genes were named hap for Hahella prodigiosin, and determined to be transcribed as a single operon, by RT-PCR experiment. Based on the hap gene mutagenesis experiments and comparative analysis with pig and red genes, we propose a prodigiosin-biosynthetic pathway in KCTC 2396.
Keyword
algicidal agenthapmarine bacteriumprodigiosin
ISSN
1017-7825
Publisher
Korea Soc-Assoc-Inst
Type
Article
Appears in Collections:
Division of Research on National Challenges > Infectious Disease Research Center > 1. Journal Articles
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