N-Benzylbenzamides: A new class of potent tyrosinase inhibitors

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Title
N-Benzylbenzamides: A new class of potent tyrosinase inhibitors
Author(s)
S J Cho; J S Roh; W S Sun; S H Kim; K D Park
Bibliographic Citation
Bioorganic & Medicinal Chemistry Letters, vol. 16, no. 10, pp. 2682-2684
Publication Year
2006
Abstract
A series of potent inhibitors of tyrosinase and their structure-activity relationships are described. N-Benzylbenzamide derivatives (1-21) with hydroxyl(s) were synthesized and tested for their tyrosinase inhibitory activity. With this series, compound 15 provided a potent tyrosinase inhibition: it effectively inhibited the oxidation of l-DOPA catalyzed by mushroom tyrosinase with an IC50 of 2.2 μM.
Keyword
4-Substituted resorcinolN-BenzylbenzamidesSARTyrosinase inhibitor
ISSN
0960-894X
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.bmcl.2006.02.018
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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