N-Benzylbenzamides: A new class of potent tyrosinase inhibitors
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- Title
- N-Benzylbenzamides: A new class of potent tyrosinase inhibitors
- Author(s)
- S J Cho; J S Roh; W S Sun; S H Kim; K D Park
- Bibliographic Citation
- Bioorganic & Medicinal Chemistry Letters, vol. 16, no. 10, pp. 2682-2684
- Publication Year
- 2006
- Abstract
- A series of potent inhibitors of tyrosinase and their structure-activity relationships are described. N-Benzylbenzamide derivatives (1-21) with hydroxyl(s) were synthesized and tested for their tyrosinase inhibitory activity. With this series, compound 15 provided a potent tyrosinase inhibition: it effectively inhibited the oxidation of l-DOPA catalyzed by mushroom tyrosinase with an IC50 of 2.2 μM.
- ISSN
- 0960-894X
- Publisher
- Elsevier
- Full Text Link
- http://dx.doi.org/10.1016/j.bmcl.2006.02.018
- Type
- Article
- Appears in Collections:
- 1. Journal Articles > Journal Articles
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