2β, 3α, 23-trihydroxyrus-12-ene-28-oic acid induces the apoptosis of human hepatoma HepG2 cells = 2β, 3α, 23-trihydroxyrus-12-ene-28-oic acid 처리에 의한 인간 간암세포주 HepG2의 apoptosis 유도

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Title
2β, 3α, 23-trihydroxyrus-12-ene-28-oic acid induces the apoptosis of human hepatoma HepG2 cells = 2β, 3α, 23-trihydroxyrus-12-ene-28-oic acid 처리에 의한 인간 간암세포주 HepG2의 apoptosis 유도
Author(s)
K H Yoo; J M Lee; J Hwang-Bo; M C Song; H J Yang; N I Baek; S H Kim; D K Kim; Byoung-Mog Kwon; M H Park; I S Chung
Bibliographic Citation
Journal of Korean Society for Applied Biological Chemistry, vol. 49, no. 4, pp. 270-275
Publication Year
2006
Abstract
2β, 3α, 23-trihydroxyrus-12-ene-28-oic acid was isolated from Trapa pseudoincisa S. et Z. It has a common structure of pentacyclic triterpenes and belongs to the amyrin ursolic acid group. The cytotoxic effect of this compound was investigated in human hepatoma cell line HepG2. 2β, 3α, 23- trihydroxyrus-12-ene-28-oic acid showed dose-dependent cytotoxicity in HepG2 cells. Confocal microscopy data showed that green fluorescence was increased in 2β, 3α, 23-trihydroxyrus-12-ene-28-oic acid treated-HepG2 cells in a time-dependent manner. 2β, 3α, 23-trihydroxyrus-12-ene-28-oic acid also increased the sub-G1 cell population of HepG2 cells as well as ladder-like DNA fragmentation. Taken together, our results indicate that 2β, 3α, 23-trihydroxyrus-12-ene-28-oic acid induced apoptosis in HepG2 cells.
Keyword
23-trihydroxyrus-12-ene-28-oic acidHepG2apoptosiscytotoxicity
ISSN
I000-0171
Publisher
Springer
Type
Article
Appears in Collections:
Division of Biomedical Research > Genome Editing Research Center > 1. Journal Articles
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