ACAT inhibition of alkamides identified in the fruits of Piper nigrum

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Title
ACAT inhibition of alkamides identified in the fruits of Piper nigrum
Author(s)
Mun Chual RhoSeung Woong Lee; Hye Ran Park; Jung Ho Choi; Ji Yun Kang; K Kim; Hyun Sun Lee; Young Kook Kim
Bibliographic Citation
Phytochemistry, vol. 68, no. 6, pp. 899-903
Publication Year
2007
Abstract
In this study, via a bioactivity-guided fractionation of MeOH extracts of the fruits of Piper nigrum, alkamide (5) and five previously-identified alkamides were isolated. Their structures were elucidated via spectroscopic analysis (1H, 13C NMR and ESI-MS), as follows: retrofractamide A (1), pipercide (2), piperchabamide D (3), pellitorin (4), dehydroretrofractamide C (5) and dehydropipernonaline (6). The IC50 values determined for the compounds were 24.5 (1), 3.7 (2), 13.5 (3), 40.5 (4), 60 (5) and 90 μM (6), according to the results of an ACAT enzyme assay system using rat liver microsomes. These compounds all inhibited cholesterol esterification in HepG2 cells.
Keyword
Acyl CoA: cholesterol acyltransferase (ACAT)AlkamidesAtherosclerosisHepG2 cellsPiper nigum L.PiperaceaeCellular cholesterol esterification
ISSN
0031-9422
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.phytochem.2006.11.025
Type
Article
Appears in Collections:
Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
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