Glabrol, an acyl-coenzyme A: Cholesterol acyltransferase inhibitor from licorice roots

Cited 14 time in scopus
Metadata Downloads
Title
Glabrol, an acyl-coenzyme A: Cholesterol acyltransferase inhibitor from licorice roots
Author(s)
Jung Ho Choi; Mun Chual RhoSeung Woong Lee; O E Kwon; Hye Ran Park; Ji Yun Kang; S H Lee; Hyun Sun Lee; K H Bae; Young Kook Kim
Bibliographic Citation
Journal of Ethnopharmacology, vol. 110, no. 3, pp. 563-566
Publication Year
2007
Abstract
Acyl-coenzyme A: cholesterol acyltransferase (ACAT) esterifies free cholesterol in the liver and the intestine. It has relations with production of lipoproteins and accumulation of cholesteryl esters of the atheroma. Therefore, ACAT inhibitors may act as antihypercholesterolemic and antiatherosclerotic agents. One isoprenyl flavonoid was isolated from ethanol extract of licorice roots. On the basis of spectral evidences, the compound was identified as glabrol (1). Compound 1 inhibited rat liver microsomal ACAT activity with an IC50 value of 24.6 μM and decreased cholesteryl ester formation with an IC50 value of 26.0 μM in HepG2 cells. In addition, 1 showed a non-competitive type of inhibition against ACAT.
Keyword
AtherosclerosisHypocholesterolemiaLicoriceAcyl-CoA: cholesterol acyltransferase
ISSN
0378-8741
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.jep.2006.10.012
Type
Article
Appears in Collections:
Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.