Farnesyl protein transferase and tumor cell growth inhibitory activities of lipiferolide isolated from Liriodendron tulipifera

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Title
Farnesyl protein transferase and tumor cell growth inhibitory activities of lipiferolide isolated from Liriodendron tulipifera
Author(s)
M K Moon; H M Oh; Byoung-Mog Kwon; N I Baek; S H Kim; J S Kim; D K Kim
Bibliographic Citation
Archives of Pharmacal Research, vol. 30, no. 3, pp. 299-302
Publication Year
2007
Abstract
The methanolic extract of the leaves of Liriodendron tulipifera was found to show inhibitory activity towards farnesyl protein transferase (FPTase). Bioassay-guided fractionation of the methanolic extract resulted in the isolation of lipiferolide, an inhibitor of FPTase. This compound inhibited the FPTase activity in a dose-dependent manner, and showed cell growth inhibitory activity against several tumor cells.
Keyword
cell growth inhibitory activityFPTaselipiferolideliriodendron tulipifera
ISSN
0253-6269
Publisher
Pharmaceutical Soc Korea
DOI
http://dx.doi.org/10.1007/BF02977609
Type
Article
Appears in Collections:
Division of Biomedical Research > Genome Editing Research Center > 1. Journal Articles
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