Farnesyl protein transferase and tumor cell growth inhibitory activities of lipiferolide isolated from Liriodendron tulipifera
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- Title
- Farnesyl protein transferase and tumor cell growth inhibitory activities of lipiferolide isolated from Liriodendron tulipifera
- Author(s)
- M K Moon; H M Oh; Byoung-Mog Kwon; N I Baek; S H Kim; J S Kim; D K Kim
- Bibliographic Citation
- Archives of Pharmacal Research, vol. 30, no. 3, pp. 299-302
- Publication Year
- 2007
- Abstract
- The methanolic extract of the leaves of Liriodendron tulipifera was found to show inhibitory activity towards farnesyl protein transferase (FPTase). Bioassay-guided fractionation of the methanolic extract resulted in the isolation of lipiferolide, an inhibitor of FPTase. This compound inhibited the FPTase activity in a dose-dependent manner, and showed cell growth inhibitory activity against several tumor cells.
- ISSN
- 0253-6269
- Publisher
- Pharmaceutical Soc Korea
- Type
- Article
- Appears in Collections:
- 1. Journal Articles > Journal Articles
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