Differential antiviral activity of benzastatin C and its dechlorinated derivative from Streptomyces nitrosporeus

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Title
Differential antiviral activity of benzastatin C and its dechlorinated derivative from Streptomyces nitrosporeus
Author(s)
J G Lee; Ick Dong Yoo; Won Gon Kim
Bibliographic Citation
Biological & Pharmaceutical Bulletin, vol. 30, no. 4, pp. 795-797
Publication Year
2007
Abstract
Benzastatin C, a 3-chloro-tetrahydroquinolone alkaloid from Streptomyces nitrosporeus, showed antiviral activity in a dose-dependant manner with EC 50 values of 1.92, 0.53, and 1.99 μg/ml against herpes simplex virus type 1 (HSV-1), herpes simplex virus type 2 (HSV-2), and vesicular stomatitis virus (VSV), respectively. In contrast, benzastatin D, the corresponding dechlorinated derivative, did not exhibit any antiviral activity. These results indicate that the antiviral activity of benzastatin C is mediated, in part, due to the chlorine moiety in its molecular structure.
Keyword
Antiviral activityBenzastatin CChloro-tetrahydroquinoloneStreptomyces nitrosporeus
ISSN
0918-6158
Publisher
Pharmaceutical Soc Japan
DOI
http://dx.doi.org/10.1248/bpb.30.795
Type
Article
Appears in Collections:
Division of Research on National Challenges > Infectious Disease Research Center > 1. Journal Articles
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