Anthraquinones, Cdc25B phosphatase inhibitors, isolated from the roots of Polygonum multiflorum thunb.

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Title
Anthraquinones, Cdc25B phosphatase inhibitors, isolated from the roots of Polygonum multiflorum thunb.
Author(s)
S G Choi; J Kim; N D Sung; Kwang Hee Son; H G Cheon; K R Kim; Byoung-Mog Kwon
Bibliographic Citation
Natural Product Research, vol. 21, no. 6, pp. 487-493
Publication Year
2007
Abstract
Three anthraquinones, Cdc25B phosphatase inhibitors, were isolated from the methanolic extract of the roots of Polygonum multiflorum Thunb. (Polygonaceae). Anthraquinones, physcion (1), emodin (2), and questin (3), inhibited the enzymatic activity of Cdc25B phosphatase with IC50 values of 62.5, 30, and 34 μg mL-1, respectively. Emodin (2) and questin (3) strongly inhibited the growth of human colon cancer cells, SW620 with GI50 values of 6.1 and 0.9 μg mL-1, respectively. Commercially available anthraquinones, chrysophanol (4), and rhein (5) also inhibited Cdc25B phosphatase with IC50 values of 10.7 and 22.1 μg mL-1, respectively.
Keyword
AnthraquinonesCdc25B phosphatasePolygonum multiflorum
ISSN
1029-2349
Publisher
T&F (Taylor & Francis)
DOI
http://dx.doi.org/10.1080/14786410601012265
Type
Article
Appears in Collections:
Division of Biomaterials Research > Industrial Bio-materials Research Center > 1. Journal Articles
Division of Biomedical Research > Genome Editing Research Center > 1. Journal Articles
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