Kaurane diterpenoids from Isodon excisus inhibit LPS-induced NF-κB activation and NO production in macrophage RAW264.7 cells

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Title
Kaurane diterpenoids from Isodon excisus inhibit LPS-induced NF-κB activation and NO production in macrophage RAW264.7 cells
Author(s)
S S Hong; S A Lee; X H Han; H Z Jin; J H Lee; D Lee; Jung Joon Lee; J T Hong; Y Kim; J S Ro; B Y Hwang
Bibliographic Citation
Journal of Natural Products, vol. 70, no. 4, pp. 632-636
Publication Year
2007
Abstract
As part of an ongoing search for plant-derived compounds that inhibit the activation of NF-κB, the methanol extract of the aerial parts of Isodon excisus was found to have significant inhibitory effects on the activation of NF-κB in murine macrophage RAW264.7 cells. Bioactivity-guided isolation of the extract yielded five new diterpenoids, excisusin A-E (1-5), along with seven known compounds, inflexarabdonin I (6), inflexarabdonin G (7), inflexin (8), inflexanin A (9), inflexanin B (10), inflexinol (11), and inflexarabdonin A (12). The structures were determined by analysis of the spectroscopic data including 2D NMR. All of the isolates were evaluated for their inhibitory effects on LPS-induced NF-κB activation and nitric oxide production in RAW264.7 cells.
ISSN
0163-3864
Publisher
Amer Chem Soc
DOI
http://dx.doi.org/10.1021/np060638+
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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