Quinolone alkaloids from evodiae fructus and their inhibitory effects on monoamine oxidase

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Title
Quinolone alkaloids from evodiae fructus and their inhibitory effects on monoamine oxidase
Author(s)
X H Han; S S Hong; D Lee; Jung Joon Lee; M S Lee; D C Moon; K Han; K W Oh; M K Lee; J S Ro; B Y Hwang
Bibliographic Citation
Archives of Pharmacal Research, vol. 30, no. 4, pp. 397-401
Publication Year
2007
Abstract
1-Methyl-2-undecyl-4(1H)-quinolone (1) was previously isolated as a selective MAO-B inhibitor from the Evodiae Fructus. Further bioassay-guided purification led to the identification of five known quinolone alkaloids, 1-methyl-2-nonyl-4(1H)-quinolone (2), 1-methyl-2-[(Z)-6-undecenyl]-4(1H)- quinolone (3), evocarpine (4), 1-methyl-2-[(6Z,9Z)-6,9-pentadecadienyl]-4(1H)- quinolone (5), and dihydroevocarpine (6). All the isolates showed more potent inhibitory effects against MAO-B compared to MAO-A. The most MAO-B selective compound 5 among the isolates inhibited MAO-B in a competitive manner, according to kinetic analyses by Lineweaver-Burk reciprocal plots.
Keyword
evodia rutaecarpaevodiae fructusmonoamine oxidase inhibitorquinolone alkaloidrutaceae
ISSN
0253-6269
Publisher
Pharmaceutical Soc Korea
DOI
http://dx.doi.org/10.1007/BF02980210
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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