Cytotoxic constituents from Angelicae Sinensis Radix

Cited 41 time in scopus
Metadata Downloads
Title
Cytotoxic constituents from Angelicae Sinensis Radix
Author(s)
Q C Chen; J P Lee; WenYi Jin; U J Youn; H J Kim; I S Lee; X F Zhang; K S Song; Y H Seong; K H Bae
Bibliographic Citation
Archives of Pharmacal Research, vol. 30, no. 5, pp. 565-569
Publication Year
2007
Abstract
Cytotoxic bioassay-guided fractionation of methanol extract of Angelicae Sinensis Radix led to the isolation of a new dimeric Z-ligustilide, named neodiligustilide (1), together with three known compounds, Z-ligustilide (2), 11(S),16(R)-dihydroxy-octadeca-9Z,17-dien-12,14-diyn-1-yl acetate (3), and 3(R),8(S)-falcarindiol (4). Among them, 2 showed the strongest cytotoxicity against L1210 and K562 cell lines with IC50 values of 2.27 ± 0.10 and 4.78 ± 0.18 μM, respectively, while 1 showed moderate cytotoxicity with IC50 values of 5.45 ± 0.19 and 9.87 ± 0.14 μM. Two polyacetylenes, 3 and 4, showed cytotoxicity only against L1210 cell line with IC50 values of 2.60 ± 0.90 and 2.87 ± 0.49 μM, respectively.
Keyword
angelicae sinensis radixcytotoxicityneodiligustilideangelica sinensis
ISSN
0253-6269
Publisher
Pharmaceutical Soc Korea
DOI
http://dx.doi.org/10.1007/BF02977650
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.