Stable transcriptional status in the apoptotic erythroid genome

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Title
Stable transcriptional status in the apoptotic erythroid genome
Author(s)
S Lee; J Hwang; J Ulaszek; Y C Kim; H Dong; H S Kim; J W Seok; B K Suh; S J Yim; D Johnson; N H Choe; Kyu Tae Chang; Z Y Ryoo; C C Tseng; A Wickrema; S M Wang
Bibliographic Citation
Biochemical and Biophysical Research Communications, vol. 359, no. 3, pp. 556-562
Publication Year
2007
Abstract
When a cell is destined for apoptosis, will its genome reprogram its transcriptional machinery to overcome the life-threatening challenge? To address this issue, we performed a genome-wide transcriptome analysis in EPO (erythropoietin) deprivation-induced apoptotic erythroid cells using the SAGE method. The results show that the transcript contents for the majority of the genes remain unchanged in the apoptotic cells, including the apoptotic genes and the heat shock genes. of the small number of genes with an altered expression, they are mainly associated with cellular structure. Our study reveals that there is no genetic reprogramming for the transcriptional machinery in the apoptotic genome. Apoptosis, as defined by programmed cell death, is not a crisis but a peaceful physiological process.
Keyword
apoptosiserythroidgene expressiongenomeSAGEtranscription
ISSN
0006-291X
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.bbrc.2007.05.168
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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