Inhibitory effect of 2-arylbenzofurans from Erythrina addisoniae on protein tyrosine phosphatase-1B

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Title
Inhibitory effect of 2-arylbenzofurans from Erythrina addisoniae on protein tyrosine phosphatase-1B
Author(s)
Min Kyun Na; Duc Manh Hoang; D Njamen; J T Mbafor; Z T Fomum; P T Thuong; Jong Seog Ahn; Won Keun Oh
Bibliographic Citation
Bioorganic & Medicinal Chemistry Letters, vol. 17, no. 14, pp. 3868-3871
Publication Year
2007
Abstract
Bioassay-guided fractionation of an EtOAc-soluble extract of the stem bark of Erythrina addisoniae (Leguminosae), using an in vitro PTP1B inhibitory assay, resulted in the isolation of three new (1-3) and three known (4-6) 2-arylbenzofuran derivatives. The new compounds were identified as 2-[2′,4′-dihydroxy-3′-(3-methylbut-2-enyl)phenyl]-6-hydroxybenzofuran (1), 2-[2′-methoxy-4′-hydroxy-5′-(3-methylbut-2-enyl)phenyl]-6-hydroxybenzofuran (2), and 2-(2′-methoxy-4′-hydroxyphenyl)-5-(3-methylbut-2-enyl)-6-hydroxybenzofuran (3). The new 2-arylbenzofurans 1-3 inhibited PTP1B activity with IC50 values ranging from 13.6 ± 1.1 to 17.5 ± 1.2 μM in vitro assay. On the basis of the data obtained, 2-arylbenzofurans with prenyl group may be considered as a new class of PTP1B inhibitors.
Keyword
2-Arylbenzofuran derivativeserythrina addisoniaeprenyl groupprotein tyrosine phosphatase-1B (PTP1B)
ISSN
0960-894X
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.bmcl.2007.05.005
Type
Article
Appears in Collections:
Ochang Branch Institute > Anticancer Agent Research Center > 1. Journal Articles
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