Synthesis and structure-activity relationship of novel indene N-oxide derivatives as potent peroxisome proliferator activated receptor γ (PPARγ) agonists

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Title
Synthesis and structure-activity relationship of novel indene N-oxide derivatives as potent peroxisome proliferator activated receptor γ (PPARγ) agonists
Author(s)
J H Ahn; M S Shin; S H Jung; J A Kim; H M Kim; S H Kim; S K Kang; K R Kim; S D Rhee; S D Park; J M Lee; Jeong-Hyung Lee; H G Cheon; S S Kim
Bibliographic Citation
Bioorganic & Medicinal Chemistry Letters, vol. 17, no. 18, pp. 5239-5244
Publication Year
2007
Abstract
A series of novel indene N-oxide derivatives were prepared by various synthetic methods and evaluated for their ability to activate PPARγ. The best PPARγ agonist in this series was 9 h, which showed an EC50 value of 15 nM.
Keyword
diabetesindene N-oxidePPARγ
ISSN
0960-894X
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.bmcl.2007.06.073
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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