Synthesis and structure-activity relationship of novel indene N-oxide derivatives as potent peroxisome proliferator activated receptor γ (PPARγ) agonists
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- Title
- Synthesis and structure-activity relationship of novel indene N-oxide derivatives as potent peroxisome proliferator activated receptor γ (PPARγ) agonists
- Author(s)
- J H Ahn; M S Shin; S H Jung; J A Kim; H M Kim; S H Kim; S K Kang; K R Kim; S D Rhee; S D Park; J M Lee; Jeong-Hyung Lee; H G Cheon; S S Kim
- Bibliographic Citation
- Bioorganic & Medicinal Chemistry Letters, vol. 17, no. 18, pp. 5239-5244
- Publication Year
- 2007
- Abstract
- A series of novel indene N-oxide derivatives were prepared by various synthetic methods and evaluated for their ability to activate PPARγ. The best PPARγ agonist in this series was 9 h, which showed an EC50 value of 15 nM.
- Keyword
- diabetesindene N-oxidePPARγ
- ISSN
- 0960-894X
- Publisher
- Elsevier
- DOI
- http://dx.doi.org/10.1016/j.bmcl.2007.06.073
- Type
- Article
- Appears in Collections:
- 1. Journal Articles > Journal Articles
- Files in This Item:
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