Anti-inflammatory and anti-allergic effects of kefir in a mouse asthma model

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Title
Anti-inflammatory and anti-allergic effects of kefir in a mouse asthma model
Author(s)
Mee Young Lee; Kyung Seop AhnOk Kyung Kwon; M J Kim; M K Kim; I Y Lee; Sei Ryang Oh; Hyeong Kyu Lee
Bibliographic Citation
Immunobiology, vol. 212, no. 8, pp. 647-654
Publication Year
2007
Abstract
Kefir is a microbial symbiont mixture that produces jelly-like grains. As a widely used neutraceutical, however, the therapeutic applicabilityof kefir is not certain. In order to investigate the pharmacological effects of kefir, we used a mouse asthma model, in which airway inflammation and airway remodeling was produced by ovalbumin sensitization and challenge. BALB/c mice sensitized and challenged to ovalbumin, were treated with kefir (50 mg/kg administered by intra-gastric mode) 1 h before the ovalbumin challenge. Kefir significantly suppressed ovalbumin-induced airway hyper-responsiveness (AHR) to inhaled methacholine. Intra-gastric administration of kefir significantly inhibited the increase in the total inflammatory cell count induced by ovalbumin, and the eosinophil count in bronchoalveolar lavage fluid (BALF). Type 2 helper T cell (Th2) cytokines, such as interleukin-4 and interleukin-13, and total immunoglobulin E (Ig E) levels, were also reduced to normal levels in bronchoalveolar lavage fluid. Histological studies demonstrate that kefir substantially inhibited ovalbumin-induced eosinophilia in lung tissue and mucus hyper-secretion by goblet cells in the airway. Kefir displayed anti-inflammatory and anti-allergic effects in a mouse asthma model and may possess new therapeutic potential for the treatment of allergic bronchial asthma.
Keyword
Airway hyper-responsivenessAsthmaInflammationKefirMucus hyper-secretionOvalbumin-induced mouse model
ISSN
0171-2985
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.imbio.2007.05.004
Type
Article
Appears in Collections:
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
Ochang Branch Institute > Division of National Bio-Infrastructure > Bio-Resource Central Bank > 1. Journal Articles
Ochang Branch Institute > 1. Journal Articles
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