Synthesis and biological evaluation of cinnamyl compounds as potent antitumor agents = 신남알데하이드 신규 골격의 유도체의 합성 및 항암활성 기전 규명

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Title
Synthesis and biological evaluation of cinnamyl compounds as potent antitumor agents = 신남알데하이드 신규 골격의 유도체의 합성 및 항암활성 기전 규명
Author(s)
Dae Seop Shin; J Kim; Dong Cho HanKwang Hee SonChang Woo Lee; Hwan Mook Kim; S H Hong; Byoung-Mog Kwon
Bibliographic Citation
Bioorganic & Medicinal Chemistry Letters, vol. 17, no. 19, pp. 5423-5427
Publication Year
2007
Abstract
A series of cinnamyl compounds related to 2′-hydroxycinnamaldehyde were synthesized and their antitumor effects against human cancer cells evaluated. Hydroxylamine derivative 6 inhibited the growth of human cancer cells and human colon tumor xenograft in nude mice. Its antitumor effects belong to the induction of apoptosis and arresting cell cycle at G2/M phase, which is confirmed by detection of apoptosis markers and cell cycle analysis.
Keyword
apoptosiscell cyclecinnamaldehyde
ISSN
0960-894X
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.bmcl.2007.07.033
Type
Article
Appears in Collections:
Division of Biomedical Research > Personalized Genomic Medicine Research Center > 1. Journal Articles
Division of Biomaterials Research > Industrial Bio-materials Research Center > 1. Journal Articles
Ochang Branch Institute > Division of Bioinfrastructure > Laboratory Animal Resource Center > 1. Journal Articles
Division of Biomedical Research > Genome Editing Research Center > 1. Journal Articles
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