Anti-tumor activity of Gastrodia elata Blume is closely associated with a GTP-Ras-dependent pathway = GTP-Ras 의존형 경로와 밀접하게 연관되어 있는 천마의 항암활성

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Title
Anti-tumor activity of Gastrodia elata Blume is closely associated with a GTP-Ras-dependent pathway = GTP-Ras 의존형 경로와 밀접하게 연관되어 있는 천마의 항암활성
Author(s)
J C Heo; S U Woo; M Son; J Y Park; Won Sik Choi; Kyu Tae Chang; Sung Uk Kim; E K Yoon; Y H Kim; H M Shin; S H Lee
Bibliographic Citation
Oncology Reports, vol. 18, no. 4, pp. 849-853
Publication Year
2007
Abstract
Gastrodia elata Blume (GEB) is an important medicinal plant in Korea. In order to confirm the anti-tumor activities of GEB extracts, we carried out various in vitro anti-tumor assays, including a wound assay and an invasion assay using an ethyl ether extract of GEB. The results showed that the GEB extract exhibits potent anti-tumor activity in vitro in a dose-dependent manner. The expression of CD44, cdc42, Timp-2 or RhoA mRNA did not change by GEB treatment, compared to that of the control. GTP-Ras, an active form of a G-coupled protein family, however, is associated with the anti-tumor activity of GEB extracts. We examined various molecular markers related to metastasis by reverse transcriptase-polymerase chain reaction with the extract of GEB-treated B16 cells. There was an increase in GTP-Ras expression by the Gastrodia elata Blume extract. Together, these results suggest that the Gastrodia elata Blume extract could have potential in alleviating tumorigenesis, by a GTP-Ras-dependent pathway; although the precise molecular mechanisms are still being examined.
Keyword
Anti-tumorB16 melanoma cellsGastrodia elata BlumeGTP-Ras-dependent pathway
ISSN
1021-335X
Publisher
Spandidos Publ Ltd
DOI
http://dx.doi.org/10.3892/or.18.4.849
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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